SOLUTIONS

INSECT PESTS

A major problem with previous RNAi insecticides: Not effective against Lepidopteran insect pests.

Lepidoptera

Targeting the Diamondback Moth, estimated to cause more than $4 billion in crop losses annually. Other targets include Fall Armyworm, cutworms, corn earworms, coddling moth and European corn borer, among others. 

Coleoptera

info here

Arachnids

info here
The primary focus of RNAissance Ag is the development of sprayable RNA pesticides, including against pests such as the Diamondback Moth. No previous RNAi product has been effective against the Diamondback Moth.  Previous RNAi insecticides required extremely high RNAi doses for Lepidoptera. RNAissance Ag's innovative technology SOLVES the Lepidoptera problem. 

RNAissance Ag is currently in field trials with our first two biopesticide sprays.

TECHNOLOGY

RNAi pesticides target an existing pathway in insect pests 

RNAissance’s insecticides work by harnessing the RNA interference (RNAi) pathway of the target organism. 

The RNAi pathway is found in the cells of both plants and animals, including insects. The RNAi pathway is thought to have first evolved in part to recognize and remove invading RNA viruses (polio virus, for example, is an RNA virus) to defend against infection.

The active pharmacological ingredient of RNAi insecticides is a double-stranded RNA (dsRNA).
The sequence of the dsRNA is designed very specifically to complement a sequence within an essential gene of the targeted insect.

The dsRNA is delivered to the insect midgut through feeding.

Once the dsRNA is inside the insect cell, it is processed by the insect’s own RNAi pathway into a smaller, single-stranded RNA, called a guide RNA. Through complementary base pairing, this RNA identifies the targeted insect gene and guides the rest of the RNAi machinery to effectively disrupt the expression of the gene. 

The microbial balance of the insect's gut is upset and microorganisms are not cleared from the insect's system, resulting in increased mortality. The insect dies. The plant and other insects are unaffected. 

OUR PARTNERS:

PLATFORM OPPORTUNITIES

RNAissance Ag offers multiple product and licensing opportunities. We look forward to discussing partnership opportunities with you. Contact us. 

Pest Control

RNAissance Ag is developing safe and effective RNAi-based products for commercial agricultural pest control. We are pursuing products for the most critical agricultural pests and ensuring formulations that are easy to use and cost effective.

Sprays & Baits

Consumers have demonstrated interest in pest control solutions that are safe and effective, without the use of dangerous chemicals. RNAissance Ag believes an RNAi-based biopesticide, in bait, spray or droplets, could be an important addition to home and garden pest control. 

Transgenic Traits

RNAissance Ag has proven that our RNA technology can be expressed in GMO tobacco plants and demonstrates a lethal response against tobacco hornworm, a Lepidoptera pest. This proof-of-concept deployed chloroplast engineering for the tobacco plants; when hornworm larvae fed on the plants, they displayed stunted growth, delayed development and higher rates of mortality than control larvae. RNAissance Ag offers this technology for license.

Manufacturing

RNAissance Ag is designing dsRNA to target White Spot Syndrome Virus in shrimp, which accounts for $1B in annual losses. Research is underway to incorporate our dnRNA into shrimp feed to target WSSV as well as other viral challenges, like Hemocyte Iridescent Virus. Current research with partners addresses dsRNA stability in water and as a granule, dosing and other factors. 

Aquaculture Health

RNAissance Ag is designing dsRNA to target White Spot Syndrome Virus in shrimp, which accounts for $1B in annual losses. Research is underway to incorporate our dnRNA into shrimp feed to target WSSV as well as other viral challenges, like Hemocyte Iridescent Virus. Current research with partners addresses dsRNA stability in water and as a granule, dosing and other factors. 
CONTACT US
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